Description

Tetrahydropyran-2-Carbonyl Chloride is a versatile and highly reactive organic acid chloride derivative of tetrahydropyran-2-carboxylic acid. This compound serves as a critical building block in advanced organic synthesis, enabling the efficient introduction of the tetrahydropyranoyl moiety. It is essential for research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries who require a reliable, high-purity reagent for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds containing chiral tetrahydropyran rings.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides where the tetrahydropyran structure imparts specific biological activity.
• Peptide Mimetics & Prodrug Development: Employed to create ester and amide derivatives, facilitating the design of peptide analogs and prodrugs with improved pharmacokinetic properties.
• Ligand & Catalyst Preparation: Acts as a precursor for synthesizing specialized ligands and organocatalysts used in asymmetric synthesis.
• Polymer Chemistry: Serves as a monomer or modifying agent for creating specialty polymers with unique thermal or solubility characteristics.
• Material Science Research: Utilized in surface functionalization and the development of novel organic frameworks and dendritic structures.

Basic Information

Product Name	Tetrahydropyran-2-Carbonyl Chloride
CAS No.	40053-81-4
Molecular Formula	C6H9ClO2
Molecular Weight	148.59 g/mol
Synonyms	2-Tetrahydropyrancarbonyl chloride; Tetrahydropyran-2-carboxylic acid chloride; 2-Oxanyl carbonyl chloride; 3,4,5,6-Tetrahydro-2H-pyran-2-carbonyl chloride; THP-COCl; Oxane-2-carbonyl chloride; Dihydropyran-2-carbonyl chloride (common misnomer)
EINECS	Contact for details

Quality Control

Our Tetrahydropyran-2-Carbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chromatography (HPLC, GC) and spectroscopic methods (IR, NMR), to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, assay, and impurity profiles is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at 2-8°C under an inert atmosphere (e.g., nitrogen or argon) due to its moisture-sensitive and reactive nature. Keep away from strong bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.