Description

n-Benzoyl-2'-Deoxy-Cytidine is a key nucleoside derivative where the exocyclic amine of the cytosine base is protected by a benzoyl group. This modification is critical for its primary role as a building block in oligonucleotide synthesis, particularly in the phosphoramidite method used for DNA and RNA production. It is an essential raw material for researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors who require high-purity, reliable intermediates for antisense therapies, PCR primers, probes, and other nucleic acid-based applications.

Application

• Oligonucleotide Synthesis: A fundamental phosphoramidite monomer for the solid-phase synthesis of DNA and RNA strands.
• Antisense & siRNA Therapeutics: Production of modified oligonucleotides for gene silencing and therapeutic applications.
• Molecular Diagnostics: Manufacture of probes and primers for PCR, qPCR, and sequencing.
• Research & Development: Used in academic and industrial labs for studying nucleic acid chemistry and developing novel biomolecules.
• Nucleoside Analogue Development: Serves as a protected intermediate in the synthesis of potential antiviral or anticancer nucleoside drugs.

Basic Information

Product Name	n-Benzoyl-2'-Deoxy-Cytidine
CAS No.	4836-13-9
Molecular Formula	C16H17N3O5
Molecular Weight	331.32 g/mol
Synonyms	N4-Benzoyl-2'-deoxycytidine; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-(benzoylamino)-2(1H)-pyrimidinone; 2'-Deoxy-N4-benzoylcytidine; dCBz; Bz-dC; N-Bz-2'-deoxycytidine; 4-N-Benzoyl-2'-deoxycytidine
EINECS	Contact for details

Quality Control

We supply n-Benzoyl-2'-Deoxy-Cytidine manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for sensitive oligonucleotide synthesis. Our products undergo rigorous quality testing, including HPLC, NMR, and MS analysis, to ensure compliance with industry standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.