Description

5'-Azido-2',5'-Dideoxycytidine is a chemically modified nucleoside analog featuring an azido group at the 5' position. This compound serves as a critical synthetic intermediate and a versatile building block in medicinal chemistry and biochemical research. It is primarily sought after by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel antiviral agents, prodrugs, and as a key precursor for click chemistry applications.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Research: Used as a modified nucleoside substrate to study enzyme mechanisms, DNA/RNA synthesis inhibition, and metabolic pathways.
• Click Chemistry: The azido functional group enables efficient copper-catalyzed azide-alkyne cycloaddition (CuAAC) for bioconjugation, labeling, and polymer synthesis.
• Probe Development: Utilized in the creation of molecular probes for investigating cellular uptake and nucleotide metabolism.
• Antiviral Agent Synthesis: Serves as a building block for analogs targeting viral polymerases, particularly in HIV and hepatitis research.

Basic Information

Product Name	5'-Azido-2',5'-Dideoxycytidine
CAS No.	4803-88-7
Molecular Formula	C9H12N6O3
Molecular Weight	252.23 g/mol
Synonyms	5'-Azido-2',5'-dideoxycytidine; 2',5'-Dideoxy-5'-azidocytidine; 1-(5-Azido-2,5-dideoxy-β-D-erythro-pentofuranosyl)cytosine; 5'-Azido-ddC; Azidodideoxycytidine; NSC 401777; 5'-N3-2',5'-ddC
EINECS	Contact for details

Quality Control

Our 5'-Azido-2',5'-Dideoxycytidine is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide a detailed Certificate of Analysis (COA) with every shipment to ensure traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.