Description

Guanylyl-(3'-5')-Uridine is a specific dinucleoside monophosphate, a fundamental building block in RNA research and synthesis. This high-purity biochemical is critical for studying RNA structure, function, and enzymatic processes like ligation. It serves as an essential reagent for molecular biologists, biochemists, and pharmaceutical researchers developing nucleotide-based therapeutics. Its defined structure makes it invaluable for creating precise oligonucleotide sequences and probing nucleic acid interactions.

Application

• Biochemical Research: A key substrate for studying RNA ligase enzymes and understanding RNA splicing mechanisms.
• Oligonucleotide Synthesis: Used as a controlled building block in the chemical and enzymatic synthesis of specific RNA sequences.
• Enzyme Kinetics & Assay Development: Employed in assays to measure the activity and specificity of nucleotidyltransferases and other RNA-modifying enzymes.
• Pharmaceutical R&D: Serves as a reference standard and starting material in the development of mRNA-based vaccines, antisense oligonucleotides, and other nucleic acid therapeutics.
• Diagnostic Probe Development: Utilized in the design and construction of labeled RNA probes for hybridization and detection applications.
• Academic Research: Fundamental tool for investigating RNA secondary structure, folding, and protein-RNA interactions.

Basic Information

Product Name	Guanylyl-(3'-5')-Uridine
CAS No.	4785-07-3
Molecular Formula	C19H23N7O13P
Molecular Weight	588.40 g/mol
Synonyms	GpU; Guanosine(3'-5')uridine; 3'-5'-Guanosine uridine phosphate; G(3'-5')U; 5'-Guanylyl-(3'->5')-uridine; GpU dinucleotide; 3'-GMP-5'-UMP; Uridylyl-(5'->3')-guanosine (reverse direction)
EINECS	Contact for details

Quality Control

Our Guanylyl-(3'-5')-Uridine is produced under stringent conditions to ensure the highest standards of purity and batch-to-batch consistency, suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous quality testing protocols, with specifications available to meet the demands of pharmaceutical R&D and advanced biochemical studies.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the sealed container to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Specific Rotation	Contact for details
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.