Description

2'-Chloro-2'-Deoxyuridine is a halogenated nucleoside analog of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and reference standard in the development of antiviral and anticancer agents, particularly those targeting DNA synthesis and repair pathways. It is essential for researchers and manufacturers in the fields of medicinal chemistry, molecular biology, and oncology drug discovery.

Application

• Medicinal Chemistry Research: A key intermediate in the synthesis of novel nucleoside-based antiviral and anticancer prodrugs.
• Biochemical Studies: Used as a substrate or inhibitor to study enzyme kinetics, particularly thymidine kinase and other nucleoside-metabolizing enzymes.
• Antiviral Agent Development: Investigated for its potential activity against DNA viruses, serving as a precursor for more potent analogs.
• Oncology Research: Employed in research exploring mechanisms of cell cycle arrest and apoptosis induction in cancer cell lines.
• Reference Standard: Utilized as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.
• DNA/RNA Synthesis Studies: Acts as a modified nucleoside to investigate DNA replication fidelity and repair mechanisms.

Basic Information

Product Name	2'-Chloro-2'-Deoxyuridine
CAS No.	4753-04-2
Molecular Formula	C9H11ClN2O5
Molecular Weight	262.65 g/mol
Synonyms	2'-Chloro-2'-deoxyuridine; 2-Chloro-2'-deoxyuridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-chloro-1,2,3,4-tetrahydropyrimidine-2,4-dione; 5-Chloro-2'-deoxyuridine; 2'-Cl-dU; NSC 38298; UdR-2'-Cl
EINECS	Contact for details

Quality Control

Our 2'-Chloro-2'-Deoxyuridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and heavy metals to ensure it meets the stringent requirements of research and development applications. Certificates of Analysis (COA) documenting all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.