Description

2'-Bromo-2'-Deoxy-D-Uridine is a halogenated nucleoside analog of deoxyuridine, where a bromine atom replaces the hydroxyl group at the 2' position of the sugar moiety. This structural modification makes it a valuable biochemical tool for studying DNA synthesis, repair mechanisms, and as a precursor in the synthesis of more complex antiviral and anticancer nucleoside analogs. It is primarily utilized by research institutions, pharmaceutical R&D departments, and diagnostic kit manufacturers engaged in molecular biology, oncology research, and antiviral drug discovery.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies of thymidylate synthase and other nucleotide-metabolizing enzymes.
• Antiviral/Anticancer Agent Development: Serves as a key synthetic intermediate in the preparation of novel nucleoside-based therapeutic candidates.
• DNA Labeling and Sequencing: Can be incorporated into DNA strands to study replication fidelity, DNA repair pathways, and for radioisotopic labeling in diagnostic assays.
• Cell Proliferation Studies: Employed in research to monitor cell division and DNA synthesis rates in various biological models.
• Reference Standard: Used as a high-purity analytical standard in quality control laboratories for pharmaceutical development.

Basic Information

Product Name	2'-Bromo-2'-Deoxy-D-Uridine
CAS No.	4753-02-0
Molecular Formula	C9H11BrN2O5
Molecular Weight	307.10 g/mol
Synonyms	5-Bromo-2'-deoxyuridine (BrdU); BrdUrd; 2'-Deoxy-5-bromouridine; 5-Bromo-1-(2-deoxy-β-D-ribofuranosyl)uracil; BUdR; NSC 38297; 5-Br-dU; Bromodeoxyuridine
EINECS	225-281-0

Quality Control

Our 2'-Bromo-2'-Deoxy-D-Uridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, detailing all specifications and test results to ensure traceability and compliance with your research or development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Melting Point	190°C - 195°C
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.