Description

4-Methoxyphenylacetyl Chloride is a versatile and highly reactive acyl chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 4-methoxyphenylacetyl moiety, a key structural feature in numerous high-value compounds. This intermediate is essential for research and production in the pharmaceutical, agrochemical, and specialty chemical industries, where it is used to create active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with analgesic, anti-inflammatory, or neurological activity.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and plant growth regulators that incorporate the methoxyphenyl group.
• Peptide Mimetics & Modifications: Employed for the acylation of amino groups in peptides and amino acid derivatives to create novel peptide-based drugs or research tools.
• Liquid Crystal & OLED Material Precursor: Acts as a starting material for synthesizing advanced organic molecules used in electronic displays and optoelectronic devices.
• Dye & Pigment Manufacturing: Serves as an intermediate in the production of specialized dyes and organic pigments.
• Polymer & Resin Modification: Used to introduce functional groups into polymer chains to alter physical properties like solubility, adhesion, or thermal stability.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D labs for exploring new synthetic pathways and creating novel chemical entities.
• Flavor & Fragrance Ingredient Synthesis: Intermediate for creating complex aromatic compounds used in high-end fragrance and flavor formulations.

Basic Information

Product Name	4-Methoxyphenylacetyl Chloride
CAS No.	4693-91-8
Molecular Formula	C9H9ClO2
Molecular Weight	184.62 g/mol
Synonyms	(4-Methoxyphenyl)acetyl Chloride; 2-(4-Methoxyphenyl)acetyl Chloride; p-Methoxyphenylacetyl Chloride; 4-Methoxybenzeneacetyl Chloride; 4-Methoxy-α-toluoyl Chloride; (4-Methoxyphenyl)acetic Acid Chloride; PMAC; 4-Methoxybenzylcarbonyl Chloride
EINECS	225-159-6

Quality Control

Our 4-Methoxyphenylacetyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for demanding synthetic applications. We employ advanced analytical techniques including HPLC, GC, and NMR to verify identity and quantify impurities. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with each shipment. Our quality system is designed to support cGMP and ISO standards for traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C/59-77°F). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.