Description

1-Phenylcyclobutanecarbonyl Chloride is a versatile and highly reactive organic building block, primarily used as a key acylating agent in advanced synthesis. Its value lies in its ability to efficiently introduce the 1-phenylcyclobutanecarbonyl moiety, a valuable structural motif in medicinal chemistry. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), especially those containing the phenylcyclobutane scaffold for potential therapeutic applications.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and insecticides, where its structure can contribute to unique biological activity.
• Peptide & Protein Modification: Serves as an acylating agent for modifying amino acids, peptides, or proteins to alter their properties or create conjugates.
• Material Science Research: Employed in the synthesis of specialized polymers, liquid crystals, or organic electronic materials that require specific aromatic-aliphatic hybrid structures.
• Chemical Biology Probes: Useful for creating activity-based probes or affinity labels to study enzyme function and biological pathways.
• Custom Synthesis & Contract Manufacturing: A valuable reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	1-Phenylcyclobutanecarbonyl Chloride
CAS No.	4620-67-1
Molecular Formula	C11H11ClO
Molecular Weight	194.66 g/mol
Synonyms	1-Phenylcyclobutanecarboxylic Acid Chloride; 1-Phenylcyclobutanoyl Chloride; Cyclobutanecarbonyl Chloride, 1-Phenyl-; 1-Phenylcyclobutanecarboxoyl Chloride; 1-Phenylcyclobutane-1-carbonyl Chloride; 1-Phenyl-1-cyclobutanecarbonyl Chloride; 1-Phenylcyclobutylcarbonyl Chloride; 1-Phenylcyclobutanecarboxylic chloride
EINECS	Contact for details

Quality Control

Our 1-Phenylcyclobutanecarbonyl Chloride is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and titration methods, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical specifications. Our quality systems are designed to support cGMP and ISO standards for customers in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as an acid chloride, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.