Description

O6-Benzyl Guanosine is a chemically modified nucleoside derivative, specifically a guanosine analog with a benzyl group at the O6 position. This modification is critical for its role as a key intermediate and building block in advanced pharmaceutical research and development. It is primarily utilized by researchers and manufacturers in the fields of nucleoside chemistry, antiviral drug discovery, and oligonucleotide synthesis. The compound's unique structure makes it valuable for probing biochemical pathways and developing novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a crucial precursor in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies to investigate DNA repair mechanisms and polymerase activity.
• Oligonucleotide Synthesis: Acts as a protected or modified monomer for the solid-phase synthesis of specialized DNA/RNA sequences for diagnostic and therapeutic applications.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to optimize the potency and selectivity of drug candidates.
• Academic Research: Utilized in universities and research institutes for fundamental studies in nucleic acid chemistry and molecular biology.

Basic Information

Product Name	O6-Benzyl Guanosine
CAS No.	4552-61-8
Molecular Formula	C17H19N5O5
Molecular Weight	373.36 g/mol
Synonyms	9-[(2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-(phenylmethoxy)-1H-purin-2-one; Guanosine, O6-benzyl-; 6-Benzyloxyguanosine; O6-Bn-Guo; 6-O-Benzylguanosine; NSC 154042; 1,9-Dihydro-6-(benzyloxy)-9-β-D-ribofuranosylpurin-2-one
EINECS	Contact for details

Quality Control

Our O6-Benzyl Guanosine is produced under controlled conditions to ensure high purity and batch-to-batch consistency. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment. We adhere to cGMP principles where applicable to support our clients in regulated research and development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.