Description

7H-1,2,3-Triazolo[4,5-D]Pyrimidin-7-One, 5-Amino-3-(2-Deoxy-β-D-Erythro-Pentofuranosyl)-3,6-Dihydro- is a high-purity nucleoside analog of significant interest in advanced pharmaceutical research and development. This compound serves as a critical building block for the synthesis of novel therapeutic agents, particularly in the fields of antiviral and anticancer drug discovery. It is primarily utilized by pharmaceutical R&D laboratories, contract research organizations (CROs), and fine chemical manufacturers engaged in developing next-generation nucleotide-based therapies.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of nucleoside analog prodrugs and active pharmaceutical ingredients (APIs).
• Antiviral Drug Research: Used in the development of novel antiviral compounds targeting DNA and RNA viruses.
• Oncology Research: Serves as a scaffold for creating potential anticancer agents that interfere with DNA replication and repair mechanisms.
• Biochemical Tool: Employed in enzymatic studies and as a substrate or inhibitor for nucleoside-metabolizing enzymes.
• Medicinal Chemistry: A valuable building block for structure-activity relationship (SAR) studies to optimize drug potency and selectivity.
• Process Development: Used in scaling up synthetic routes for GMP-grade material production.

Basic Information

Item	Details
Product Name	7H-1,2,3-Triazolo[4,5-D]Pyrimidin-7-One, 5-Amino-3-(2-Deoxy-β-D-Erythro-Pentofuranosyl)-3,6-Dihydro-
CAS No.	4546-73-0
Molecular Formula	C10H13N7O4
Molecular Weight	295.26 g/mol
Synonyms	5-Amino-3-(2-deoxy-β-D-erythro-pentofuranosyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 5-Amino-7-(2-deoxy-β-D-ribofuranosyl)-7H-[1,2,3]triazolo[4,5-d]pyrimidine; 5-Amino-3-(2-deoxy-β-D-ribofuranosyl)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-one; 5-Amino-3-(2-deoxy-β-D-ribofuranosyl)-3,6-dihydro-7H-[1,2,3]triazolo[4,5-d]pyrimidin-7-one; 8-Aza-7-deaza-2'-deoxyadenosine; 8-Aza-7-deaza-dA; Triazolopyrimidine nucleoside analog
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems. Every batch is subjected to rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and MS. We provide comprehensive Certificates of Analysis (COA) detailing all specifications, ensuring full traceability and compliance with the stringent requirements of pharmaceutical R&D. Specifications can be aligned with early-phase clinical development standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.