Description

n-Benzoyl-2'-Deoxy-Adenosine is a chemically modified nucleoside derivative, specifically a benzoylated analog of the fundamental DNA building block 2'-deoxyadenosine. This modification is critical for protecting the nucleoside during oligonucleotide synthesis, ensuring high coupling efficiency and purity in the final product. It is an essential intermediate for pharmaceutical research, diagnostic development, and the production of synthetic DNA and antisense oligonucleotides, serving biotechnology, pharmaceutical, and academic research sectors globally.

Application

• Solid-Phase Oligonucleotide Synthesis (SPOS): A key protected phosphoramidite precursor for automated DNA and RNA synthesis.
• Antisense & siRNA Therapeutics: Used in the research and manufacturing of gene-silencing drugs and therapeutic oligonucleotides.
• Diagnostic Probe Development: Essential for creating labeled probes for PCR, sequencing, and microarray technologies.
• Pharmaceutical Intermediate: Serves as a building block in the synthesis of nucleoside-based antiviral and anticancer agents.
• Biochemical Research: A valuable tool for studying enzyme mechanisms, nucleic acid interactions, and metabolic pathways.
• GMP Manufacturing: Supplied under controlled conditions for use in the production of clinical-grade oligonucleotides.

Basic Information

Product Name	n-Benzoyl-2'-Deoxy-Adenosine
CAS No.	4546-72-9
Molecular Formula	C17H17N5O4
Molecular Weight	355.35 g/mol
Synonyms	N6-Benzoyl-2'-deoxyadenosine; 2'-Deoxy-N6-benzoyladenosine; N-Bz-dA; Bz-dA; 9-[(2R,3S,5R)-3-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-6-benzoylpurine; 6-Benzamido-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine; N6-Benzoyl-deoxyadenosine; Protected 2'-Deoxyadenosine
EINECS	Contact for details

Quality Control

Our n-Benzoyl-2'-Deoxy-Adenosine is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide comprehensive Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with relevant industry standards for research and GMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.