Description

(1R-Trans)-2,2-Dimethyl-3-(2-Methylprop-1-Enyl)Cyclopropanecarbonyl Chloride is a high-purity, optically active cyclopropane derivative that serves as a critical chiral building block in advanced organic synthesis. Its value lies in its role as a reactive acyl chloride intermediate, enabling the efficient introduction of the chrysanthemic acid moiety into target molecules. This compound is essential for research and production in the agrochemical and pharmaceutical industries, particularly for the synthesis of pyrethroid insecticides and other bioactive compounds requiring precise stereochemistry.

Application

• Key Intermediate for Pyrethroid Synthesis: A crucial precursor in the manufacturing of synthetic pyrethroid insecticides such as allethrin, phenothrin, and other analogs, where the (1R-trans) stereochemistry is vital for biological activity.
• Pharmaceutical Building Block: Used in the research and development of chiral active pharmaceutical ingredients (APIs) that incorporate the cyclopropane structure for enhanced metabolic stability and biological profile.
• Fine Chemical Synthesis: Employed in academic and industrial laboratories for the preparation of complex natural products, flavors, and fragrances that require the chrysanthemate skeleton.
• Agrochemical Research: Serves as a standard or starting material in the discovery and optimization of new crop protection agents with improved efficacy and environmental safety.
• Derivatization Agent: Functions as an acylating agent to introduce the 2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropanecarbonyl group onto amines, alcohols, or other nucleophiles.

Basic Information

Product Name	(1R-Trans)-2,2-Dimethyl-3-(2-Methylprop-1-Enyl)Cyclopropanecarbonyl Chloride
CAS No.	4489-14-9
Molecular Formula	C12H17ClO
Molecular Weight	212.72 g/mol
Synonyms	(+)-trans-Chrysanthemoyl chloride; (1R,3R)-2,2-Dimethyl-3-(2-methylprop-1-en-1-yl)cyclopropane-1-carbonyl chloride; (1R)-trans-Chrysanthemic acid chloride; (1R,3R)-Chrysanthemoyl chloride; d-trans-Chrysanthemoyl chloride; (1R,3R)-2,2-Dimethyl-3-(2-methylpropenyl)cyclopropanecarbonyl chloride; (+)-trans-2,2-Dimethyl-3-(2-methyl-1-propenyl)cyclopropanecarbonyl chloride
EINECS	Contact for details

Quality Control

Our (1R-Trans)-2,2-Dimethyl-3-(2-Methylprop-1-Enyl)Cyclopropanecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC and GC, to ensure high chemical and optical purity consistent with industry standards for advanced intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Chiral Purity (HPLC)	≥ 98.0% (1R,3R isomer)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.