Description

4-Nitrobenzyl Chloroformate is a versatile and highly reactive chemical intermediate primarily used as a protecting agent in organic synthesis. Its value lies in its ability to selectively protect amine and alcohol functional groups, enabling complex multi-step reactions in the production of pharmaceuticals and fine chemicals. This compound is essential for research laboratories and industrial manufacturers engaged in the synthesis of peptides, active pharmaceutical ingredients (APIs), and other high-value specialty molecules.

Application

• Peptide Synthesis: A key reagent for the introduction of the 4-nitrobenzyloxycarbonyl (4-NZ) protecting group on amino acids, facilitating solid-phase and solution-phase peptide synthesis.
• Pharmaceutical Intermediates: Used in the multi-step synthesis of complex drug molecules, particularly where temporary amine protection is required under specific reaction conditions.
• Fine Chemical Production: Serves as a building block and protecting group agent in the manufacture of agrochemicals, dyes, and advanced material precursors.
• Bioconjugation Chemistry: Employed in the modification of biomolecules, such as proteins and oligonucleotides, for research and diagnostic applications.
• Academic & Industrial R&D: A staple reagent in process chemistry development and methodological research within organic chemistry laboratories.

Basic Information

Product Name	4-Nitrobenzyl Chloroformate
CAS No.	4457-32-3
Molecular Formula	C8H6ClNO4
Molecular Weight	215.59 g/mol
Synonyms	4-Nitrobenzyl Chloroformate; p-Nitrobenzyl Chloroformate; 4-Nitrobenzyloxycarbonyl Chloride; 4-NZ-Cl; Chloroformic Acid 4-Nitrobenzyl Ester; (4-Nitrobenzyl) Carbonochloridate; p-Nitrobenzyl Chloroformate; NSC 401119
EINECS	224-707-8

Quality Control

Our 4-Nitrobenzyl Chloroformate is produced under stringent quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP guidelines where applicable to support its use in regulated pharmaceutical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.