Description

α-Thymidine CAS NO 4449-43-8 is a high-purity nucleoside derivative, a key building block in oligonucleotide synthesis and biochemical research. Its primary value lies in its role as a critical precursor for the development of modified nucleic acids, enabling advanced studies in molecular biology and therapeutic applications. This product is essential for pharmaceutical R&D laboratories, biotechnology companies, and academic institutions focused on antiviral drug discovery, genetic research, and the synthesis of novel DNA/RNA analogs.

Application

• Oligonucleotide Synthesis: A vital phosphoramidite precursor for solid-phase synthesis of DNA and RNA strands.
• Antiviral Drug Development: Serves as a core scaffold in the research and production of nucleoside analog therapeutics.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies involving thymidine kinase and other nucleoside-metabolizing enzymes.
• Labeled Compound Production: A starting material for synthesizing radiolabeled (e.g., tritiated) or fluorescently tagged thymidine derivatives for tracer studies.
• Cell Culture & Diagnostics: Employed in specialized cell proliferation assays and diagnostic kit formulations.
• Academic & Pharmaceutical R&D: Fundamental research tool for investigating DNA replication, repair mechanisms, and nucleic acid chemistry.

Basic Information

Product Name	α-Thymidine
CAS No.	4449-43-8
Molecular Formula	C10H14N2O5
Molecular Weight	242.23 g/mol
Synonyms	1-(2-Deoxy-α-D-erythro-pentofuranosyl)thymine; α-Thymidine; 2'-Deoxy-α-thymidine; α-D-2'-Deoxythymidine; Thymidine, α-anomer; α-TdR; NSC 48225; α-Deoxythymidine
EINECS	Contact for details

Quality Control

α-Thymidine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or production specifications. Our quality commitment supports applications requiring high-purity biochemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.