Description

2'-Deoxy-3',5'-Di-o-(4-Methylbenzoyl)-Uridine is a key protected nucleoside derivative, specifically a uridine analog with benzoyl-protected hydroxyl groups. This compound is critically important as a versatile synthetic intermediate in the production of modified oligonucleotides and nucleoside-based pharmaceuticals. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for applications in antisense therapy, prodrug development, and nucleic acid chemistry.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel antiviral and anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used in the preparation of modified DNA/RNA strands for research, diagnostic probes, and therapeutic antisense oligonucleotides.
• Prodrug Development: Acts as a protected precursor molecule that can be further functionalized to create prodrugs with enhanced bioavailability.
• Biochemical Research: Employed in studies of enzyme mechanisms, nucleic acid metabolism, and as a substrate for nucleoside kinases.
• Labeling and Tracing: Can be utilized as a starting material for the synthesis of radiolabeled or fluorescently tagged nucleosides for tracking studies.

Basic Information

Product Name	2'-Deoxy-3',5'-Di-o-(4-Methylbenzoyl)-Uridine
CAS No.	4449-38-1
Molecular Formula	C25H24N2O8
Molecular Weight	480.47 g/mol
Synonyms	3',5'-Di-O-p-toluoyl-2'-deoxyuridine; 2'-Deoxyuridine, 3',5'-bis(4-methylbenzoate); 3',5'-Di-O-(4-methylbenzoyl)-2'-deoxyuridine; p-Toluoyl-protected deoxyuridine; 2'-dUrd(Bz)2; Uridine, 2'-deoxy-, 3',5'-bis(4-methylbenzoate); Protected Deoxyuridine Intermediate
EINECS	Contact for details

Quality Control

Our 2'-Deoxy-3',5'-Di-o-(4-Methylbenzoyl)-Uridine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and synthesis. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.