Description

Coumermycin A1 CAS NO 4434-05-3 is a potent aminocoumarin antibiotic that functions as a specific inhibitor of bacterial DNA gyrase. This compound is of significant value in biochemical and microbiological research for studying DNA replication, supercoiling, and topoisomerase mechanisms. It is primarily utilized by researchers in pharmaceutical development, academic institutions, and biotechnology companies focused on antibacterial discovery and molecular biology.

Application

• Biochemical Research: Used as a specific inhibitor of bacterial DNA gyrase (topoisomerase II) to study DNA replication, transcription, and supercoiling dynamics.
• Antibacterial Mechanism Studies: Serves as a key tool compound for investigating the mode of action of aminocoumarin-class antibiotics and bacterial resistance mechanisms.
• Pharmaceutical R&D: Employed in screening assays and as a lead compound or reference standard in the development of novel antibacterial agents.
• Microbiology: Used in selective media and research to study Gram-positive bacterial pathogens, particularly Staphylococcus and Streptococcus species.
• Enzyme Inhibition Assays: Acts as a potent inhibitor in enzymatic assays to characterize gyrase activity and evaluate potential synergistic or antagonistic effects with other drugs.

Basic Information

Product Name	Coumermycin A1
CAS No.	4434-05-3
Molecular Formula	C₆₆H₇₄N₄O₂₃
Molecular Weight	1291.31 g/mol
Synonyms	Coumermycin A1; Notomycin; Sugordomycin; 5,5'-Carbonylbis[N,N'-bis(3-methyl-1-oxobutyl)-4-hydroxy-2-oxo-1,5,7,8-tetrahydro-2H-1-benzopyrano[4,3-b]pyridine-6-carboxamide]; Antibiotic G 5992; Antibiotic X 465 A; G 5992; X 465 A
EINECS	224-654-9

Quality Control

Our Coumermycin A1 is produced and tested under strict quality management systems. Each batch undergoes comprehensive analysis including identification, purity assay, and impurity profiling to ensure it meets the high standards required for research applications. A Certificate of Analysis (COA) detailing specific results for parameters such as HPLC purity, water content, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to light brown powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.