Description

3β-[(2-o-Acetyl-6-Deoxy-3-o-Methyl-α-L-Mannopyranosyl)Oxy]-14-Hydroxy-5β-Card-20(22)-Enolide CAS NO 4420-65-9 is a high-purity, specialized cardiac glycoside derivative, a critical intermediate in advanced pharmaceutical research and development. Its value lies in its precise molecular structure, which is essential for studying cardiac activity and synthesizing novel therapeutic agents. This compound is primarily needed by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on cardiovascular drug discovery and process chemistry.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardiac glycosides and related therapeutic compounds.
• Biochemical Research: Used as a reference standard and active probe in studies of sodium-potassium ATPase (Na⁺/K⁺-ATPase) inhibition and cardiac cell signaling pathways.
• Medicinal Chemistry: Serves as a crucial scaffold for structure-activity relationship (SAR) studies to develop new cardiovascular agents with optimized efficacy and safety profiles.
• Process Development: Employed in the scale-up and optimization of synthetic routes for complex, biologically active molecules in a GMP environment.
• Analytical Standard: Provides a high-purity benchmark for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.

Basic Information

Product Name	3β-[(2-o-Acetyl-6-Deoxy-3-o-Methyl-α-L-Mannopyranosyl)Oxy]-14-Hydroxy-5β-Card-20(22)-Enolide
CAS No.	4420-65-9
Molecular Formula	C₃₂H₄₈O₁₀
Molecular Weight	592.72 g/mol
Synonyms	3β-[(2-O-Acetyl-6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-14-hydroxy-5β-card-20(22)-enolide; Acetyldigitoxin-α-L-rhamnoside; α-Acetyldigoxin; 16-Acetylgitoxin; Strophanthidin 3-(2-O-acetyl-6-deoxy-3-O-methyl-α-L-mannopyranoside); NSC 107679; 3β-[(2-O-Acetyl-6-deoxy-3-O-methyl-α-L-mannopyranosyl)oxy]-14-hydroxycard-20(22)-enolide
EINECS	Contact for details

Quality Control

Our 3β-[(2-o-Acetyl-6-Deoxy-3-o-Methyl-α-L-Mannopyranosyl)Oxy]-14-Hydroxy-5β-Card-20(22)-Enolide is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant industry standards, and specifications can be aligned with client requirements for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.