Description

5 β-Pregnane-3 Alpha,6 Alpha,20 α-Triol CAS NO 4420-37-5 is a high-purity steroid derivative, specifically a trihydroxy pregnane, that serves as a critical intermediate and reference standard in advanced pharmaceutical research and development. Its defined stereochemistry and functional groups make it a valuable building block for synthesizing more complex steroid-based compounds and for use in analytical method development. This compound is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors. It is primarily utilized in the synthesis of specialized steroid hormones and as a certified reference material (CRM) for quality control and regulatory compliance.

Application

• Pharmaceutical Intermediate: A key starting material or synthetic intermediate in the production of specialized steroid hormones and related therapeutic agents.
• Reference Standard: Used as a high-purity Certified Reference Material (CRM) for calibrating analytical instruments, validating methods, and ensuring quality control in pharmaceutical labs.
• Biochemical Research: Employed in metabolic pathway studies, enzyme substrate research, and investigations into steroid biosynthesis and function.
• Analytical Chemistry: Serves as an analytical standard for techniques like HPLC, GC-MS, and NMR to identify and quantify related steroids in complex mixtures.
• Process Development: Used in the scale-up and optimization of synthetic routes for steroid-based active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5 β-Pregnane-3 Alpha,6 Alpha,20 α-Triol
CAS No.	4420-37-5
Molecular Formula	C₂₁H₃₆O₃
Molecular Weight	336.51 g/mol
Synonyms	5β-Pregnane-3α,6α,20α-triol; 3α,6α,20α-Trihydroxy-5β-pregnane; 20α-Hydroxy-5β-pregnane-3α,6α-diol; Pregnane-3α,6α,20α-triol (5β-); 5β-Pregnanetriol; Allopregnanetriol (archaic); NSC 113986
EINECS	Contact for details

Quality Control

Our 5 β-Pregnane-3 Alpha,6 Alpha,20 α-Triol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and tests for residual solvents and moisture to ensure it meets stringent specifications for research and pharmaceutical use. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture. For long-term storage, consider using a desiccator.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.