Description

N2-Acetyl-2'-Deoxyguanosine is a chemically modified nucleoside derivative, specifically an acetylated form of deoxyguanosine. This modification is critical for research and development in nucleic acid chemistry, providing a protected intermediate for oligonucleotide synthesis and biochemical studies. It is primarily utilized by pharmaceutical R&D teams, diagnostic developers, and academic researchers focused on nucleotide analog development, antiviral agent research, and molecular biology applications.

Application

• Oligonucleotide Synthesis: Serves as a key protected building block (phosphoramidite) in the solid-phase synthesis of DNA and RNA sequences for research and therapeutic applications.
• Biochemical Research: Used as a standard or substrate in enzymatic studies involving DNA polymerases, nucleoside kinases, and other nucleotide-metabolizing enzymes.
• Antiviral & Anticancer Agent Development: Acts as a precursor or model compound in the research and synthesis of novel nucleoside analog prodrugs targeting viral replication or cancer cell proliferation.
• Diagnostic Probe Manufacturing: Employed in the creation of labeled nucleotides (e.g., fluorescent, radioactive) for use in hybridization assays, sequencing, and microarray technologies.
• Metabolite & Biomarker Studies: Useful as a reference standard in analytical methods (LC-MS, HPLC) for detecting and quantifying modified nucleosides in biological samples.
• Stable Isotope Labeling: Can be used to synthesize isotopically labeled (e.g., 13C, 15N) internal standards for mass spectrometry-based proteomics and metabolomics.

Basic Information

Product Name	N2-Acetyl-2'-Deoxyguanosine
CAS No.	4318-06-3
Molecular Formula	C12H15N5O5
Molecular Weight	309.28 g/mol
Synonyms	2'-Deoxy-N2-acetylguanosine; 2'-Deoxyguanosine, N2-acetyl-; 1-(2-Deoxy-β-D-erythro-pentofuranosyl)-N2-acetylguanine; N-Acetyldeoxyguanosine; N2-Acetylguanine deoxyriboside; dG(Ac); Ac-dG; N2-Ac-dG
EINECS	Contact for details

Quality Control

Our N2-Acetyl-2'-Deoxyguanosine is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for research and development. Each lot undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (NMR, MS). Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to a comprehensive quality management system to support our clients' needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.