Description

(S)-2-Phthalimidopropionyl Chloride is a high-purity chiral building block and key pharmaceutical intermediate. This compound is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs), particularly in the development of β-lactam antibiotics and other chiral therapeutics. It is essential for research and production in the pharmaceutical, biotechnology, and fine chemical sectors where precise stereochemistry is required.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the production of β-lactam antibiotics and other enantiopure drugs.
• Peptide Synthesis: Used as an activated acylating agent in the preparation of modified peptides and peptidomimetics.
• Asymmetric Synthesis: Serves as a versatile building block in catalytic asymmetric reactions to construct complex molecular architectures.
• Protease Inhibitor Development: Employed in the research and synthesis of enzyme inhibitors targeting specific proteases.
• Chemical Biology Probes: Utilized for labeling and modifying biomolecules to study biological pathways.
• Custom Synthesis: A critical starting material for contract research organizations (CROs) and CDMOs developing proprietary compounds.

Basic Information

Product Name	(S)-2-Phthalimidopropionyl Chloride
CAS No.	4306-25-6
Molecular Formula	C11H8ClNO3
Molecular Weight	237.64 g/mol
Synonyms	(S)-2-(1,3-Dioxoisoindolin-2-yl)propanoyl Chloride; (S)-N-Phthaloylalanine Chloride; L-N-Phthaloylalanyl Chloride; (S)-2-Phthalimido-propionyl Chloride; (S)-2-(Phthalimido)propionyl Chloride; (S)-N-Phthaloylalanyl Chloride; (S)-2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)propanoyl Chloride
EINECS	224-350-7

Quality Control

Our (S)-2-Phthalimidopropionyl Chloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the stringent requirements for pharmaceutical intermediate applications. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming identity, purity, and enantiomeric excess.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.