Description

Thymidylyl-(3',5')-2'-Deoxyguanosine is a defined dinucleotide compound, specifically a thymidine-guanosine dinucleoside monophosphate. This product is a critical building block and research tool in the fields of molecular biology and nucleic acid chemistry. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for oligonucleotide synthesis, structural studies, and enzymatic research.

Application

• Oligonucleotide Synthesis: Serves as a key intermediate or reference standard in the chemical and enzymatic synthesis of specific DNA sequences.
• Biochemical Research: Used as a substrate or inhibitor in studies of DNA polymerases, nucleases, and other nucleic acid-metabolizing enzymes.
• Structural Studies: Employed in X-ray crystallography and NMR spectroscopy to investigate DNA structure, dynamics, and protein-nucleic acid interactions.
• Diagnostic Probe Development: Acts as a component in the design and calibration of hybridization probes and primers for genetic testing.
• Antiviral/Anticancer Research: Investigated as a potential precursor or model compound in the development of nucleoside analogue therapeutics.
• Quality Control Standard: Used as a high-purity reference material for analytical method development and validation in QC laboratories.

Basic Information

Product Name	Thymidylyl-(3',5')-2'-Deoxyguanosine
CAS No.	4251-20-1
Molecular Formula	C21H27N7O12P
Molecular Weight	600.46 g/mol
Synonyms	d(TpG); Thymidylyl(3'→5')-2'-deoxyguanosine; 2'-Deoxyguanylyl-(5'→3')-thymidine; TpdG; Thymidine 5'-(3-(2-deoxyguanosine 5'-phosphate)); 5'-Thymidylic acid, 3'-(5'-guanylic acid) ester, 2'-deoxy-; d(TpG) Dinucleotide; pdTpdG
EINECS	Contact for details

Quality Control

Our Thymidylyl-(3',5')-2'-Deoxyguanosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR for structural confirmation, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to ensure traceability and compliance with your research or production standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as indicated on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.