Description

Bufa-9(11),20,22-Trienolide, 3,11,14-Trihydroxy-12-Oxo-, (3β,5β)- is a specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the synthesis of novel therapeutic agents. It serves the needs of advanced R&D laboratories and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardiac glycosides and other bioactive molecules for drug discovery programs.
• Biochemical Research: Used as a reference standard or probe in studies investigating sodium-potassium ATPase (Na+/K+-ATPase) inhibition and related cellular signaling pathways.
• Medicinal Chemistry: Serves as a core scaffold for the structural modification and development of new chemical entities with potential therapeutic applications.
• Academic Research: Employed in university and institutional labs for pharmacological studies related to cardiotonic steroids and their mechanisms of action.
• Fine Chemical Synthesis: Utilized in multi-step organic synthesis to create complex, high-value target molecules for various applications.

Basic Information

Product Name	Bufa-9(11),20,22-Trienolide, 3,11,14-Trihydroxy-12-Oxo-, (3β,5β)-
CAS No.	4236-48-0
Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51 g/mol
Synonyms	12-Oxobufalin; 3β,5β,14-Trihydroxy-12-oxobufa-9(11),20,22-trienolide; 12-Oxo-14,15-dihydrobufalin; 12-Ketobufalin; Bufa-9(11),20,22-trienolide-3,11,14-triol-12-one, (3β,5β)-; NSC 125931; 12-Oxobufa-9(11),20,22-trienolide-3,11,14-triol
EINECS	Contact for details

Quality Control

Our Bufa-9(11),20,22-Trienolide is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (IR, NMR, MS), to ensure it meets the stringent requirements of research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. This compound is light-sensitive (store away from light) and should be handled under inert atmosphere where appropriate to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.