Description

Adenosine 5'-(Tetrahydrogen Triphosphate), 3'-Amino-3'-Deoxy- is a chemically modified nucleotide analog where the 3'-hydroxyl group of the ribose sugar is replaced by an amino group, while retaining the high-energy triphosphate moiety. This unique structure makes it a critical biochemical tool for studying and manipulating enzymatic processes, particularly those involving ATP-dependent enzymes and nucleic acid polymerases. It is essential for researchers and developers in pharmaceutical discovery, molecular biology, and enzymology who require precise probes to investigate reaction mechanisms, develop inhibitors, or create modified nucleic acids.

Application

• Enzyme Mechanism Studies: Used as a substrate analog to probe the active sites and catalytic mechanisms of ATP-dependent kinases, synthetases, and helicases.
• Nucleic Acid Research: Acts as a terminator or incorporator in enzymatic synthesis for creating amino-modified oligonucleotides, useful for labeling and conjugation.
• Pharmaceutical Development: Serves as a precursor or intermediate in the synthesis of novel nucleotide-based therapeutics, including potential antiviral or anticancer agents.
• Biochemical Assay Development: Employed in high-throughput screening (HTS) assays to identify modulators of specific ATP-utilizing enzymes.
• Structural Biology: Utilized in X-ray crystallography and NMR studies to determine enzyme-ligand complex structures.
• Diagnostic Reagent Formulation: Can be incorporated into enzymatic detection systems for clinical diagnostics and biosensors.

Basic Information

Product Name	Adenosine 5'-(Tetrahydrogen Triphosphate), 3'-Amino-3'-Deoxy-
CAS No.	4209-30-7
Molecular Formula	C10H17N6O12P3
Molecular Weight	506.18 g/mol
Synonyms	3'-Amino-3'-deoxy-ATP; 3'-Amino-3'-deoxyadenosine 5'-triphosphate; 3'-NH2-3'-dATP; 3'-Amino-2',3'-dideoxy-ATP; ATP, 3'-amino-3'-deoxy-; Adenosine-5'-triphosphate, 3'-amino-3'-deoxy-; 3'-Amino-2',3'-didehydro-2',3'-dideoxyadenosine triphosphate (related form); 3'-Amino-dATP
EINECS	Contact for details

Quality Control

Our Adenosine 5'-(Tetrahydrogen Triphosphate), 3'-Amino-3'-Deoxy- is manufactured under controlled conditions to ensure high purity and batch-to-batch consistency suitable for sensitive research applications. Quality is verified through a comprehensive suite of analytical techniques including HPLC, NMR, and mass spectrometry. A detailed Certificate of Analysis (COA) providing purity, identity, and impurity profiles is supplied with each batch to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder or solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 3.0%
pH (1% Solution)	Contact for details
Biological Activity	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.