Description

Clonidine Hydrochloride is a high-purity pharmaceutical active ingredient (API) and research chemical. It is a centrally-acting α-2 adrenergic agonist with significant therapeutic importance. This compound is essential for the formulation of antihypertensive medications and is also utilized in neurological and psychiatric research. We supply CAS 4205-91-8 to meet the stringent demands of the global pharmaceutical and life science industries.

Application

• Pharmaceutical API: Primary active ingredient in prescription medications for the treatment of hypertension (high blood pressure).
• Neurological Research: Used in preclinical studies to investigate central nervous system (CNS) pathways, pain management, and opioid withdrawal symptoms.
• Psychiatric Research: Employed in research models for anxiety, attention deficit hyperactivity disorder (ADHD), and Tourette syndrome.
• Analytical Reference Standard: Serves as a certified reference material (CRM) for quality control and method development in analytical laboratories.
• Veterinary Medicine: Applied in veterinary practice for sedation and analgesia in certain animal species.
• Formulation Development: Used in the R&D of novel drug delivery systems, including transdermal patches and controlled-release tablets.

Basic Information

Product Name	Clonidine Hydrochloride
CAS No.	4205-91-8
Molecular Formula	C9H10Cl2N3·HCl
Molecular Weight	266.56 g/mol
Synonyms	Clonidine HCl; 2-[(2,6-Dichlorophenyl)imino]imidazolidine monohydrochloride; Catapres; Dixarit; Isoglaucon; ST-155; N-(2,6-Dichlorophenyl)-4,5-dihydro-1H-imidazol-2-amine hydrochloride
EINECS	224-121-2

Quality Control

Our Clonidine Hydrochloride is manufactured under strict quality management systems. Each batch is tested to ensure it meets high-purity standards suitable for pharmaceutical research and development. We provide comprehensive Certificates of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications can be aligned with major pharmacopoeial standards such as USP, EP, or BP upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference standard
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any individual impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.