Description

3β,16β-Bis(Acetyloxy)-14,15β-Epoxy-5-Hydroxy-5β-Bufa-20,22-Dienolide is a high-purity, specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This compound serves as a critical advanced pharmaceutical intermediate and a valuable reference standard for research and development. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of novel therapeutic agents and in-depth pharmacological studies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardioactive steroids and other therapeutic bufadienolide derivatives.
• Reference Standard: Used as a high-purity analytical standard in quality control (QC) and research laboratories for method development and compound identification.
• Biochemical Research: Employed in pharmacological and toxicological studies to investigate the structure-activity relationships (SAR) of bufadienolides.
• Academic Research: A valuable tool for universities and research institutions studying natural product chemistry, steroid biosynthesis, and cardiac glycoside mechanisms.
• Preclinical Development: Serves as a starting material or intermediate in the early-stage development of potential drug candidates targeting specific ion channels or enzymes.

Basic Information

Product Name	3β,16β-Bis(Acetyloxy)-14,15β-Epoxy-5-Hydroxy-5β-Bufa-20,22-Dienolide
CAS No.	4189-91-7
Molecular Formula	C₂₆H₃₄O₈
Molecular Weight	474.55 g/mol
Synonyms	14β,15β-Epoxy-3β,16β-diacetoxy-5β-bufa-20,22-dienolide; 3β,16β-Diacetoxy-14β,15β-epoxy-5β-bufa-20,22-dienolide; 5β-Bufa-20,22-dienolide, 3β,16β-bis(acetyloxy)-14,15β-epoxy-; Bufalin 3,16-diacetate 14,15-epoxide; 14,15-Epoxy-3,16-diacetoxybufa-20,22-dienolide; 3β,16β-Diacetoxy-14β,15β-epoxybufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 3β,16β-Bis(Acetyloxy)-14,15β-Epoxy-5-Hydroxy-5β-Bufa-20,22-Dienolide is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing, including HPLC for purity and spectroscopic identification (IR, NMR), to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant use and inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.