Description

12-α-Hydroxy-3-Oxo-5-β-Cholanoicacid is a high-purity bile acid derivative, a key intermediate in the synthesis of pharmaceutical compounds. This compound matters for its role in developing therapeutic agents targeting liver and metabolic functions. It is primarily needed by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic research institutions focused on hepatology and steroid chemistry.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of ursodeoxycholic acid (UDCA) analogs and other hepatoprotective drugs.
• Biochemical Research: Used as a reference standard and reagent in studies of bile acid metabolism, liver function, and cholestasis.
• Fine Chemical Synthesis: Serves as a chiral starting material or advanced intermediate in the production of complex steroid-based molecules.
• Metabolic Pathway Studies: Employed in in-vitro and in-vivo research to investigate the enterohepatic circulation and signaling pathways of bile acids.
• Quality Control Standard: Utilized as an analytical standard in HPLC and LC-MS methods for the quantification of bile acids in biological samples and pharmaceutical formulations.

Basic Information

Product Name	12-α-Hydroxy-3-Oxo-5-β-Cholanoicacid
CAS No.	4185-01-7
Molecular Formula	C24H38O4
Molecular Weight	390.56 g/mol
Synonyms	12α-Hydroxy-3-oxo-5β-cholan-24-oic Acid; 3-Oxo-12α-hydroxy-5β-cholan-24-oic Acid; 12α-Hydroxy-3-oxolithocholic Acid; 3-Keto-12α-hydroxylithocholic Acid; 12α-Hydroxy-3-oxo-5β-cholanoic Acid; 5β-Cholan-24-oic acid, 12α-hydroxy-3-oxo-; 12α-Hydroxy-3-keto-5β-cholanoic Acid
EINECS	224-059-8

Quality Control

Our 12-α-Hydroxy-3-Oxo-5-β-Cholanoicacid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep the container tightly sealed to protect the light-sensitive material from degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.