Description

(2-Bromoethyl)-Phosphorylchloride is a versatile organophosphorus building block characterized by its reactive bromoethyl and phosphoryl chloride functional groups. This compound is critical for the synthesis of complex molecules, particularly in the development of pharmaceuticals, agrochemicals, and specialty materials. It is primarily sought after by research chemists and process development scientists in the fine chemical, pharmaceutical, and crop protection industries for constructing novel chemical entities and intermediates.

Application

• Pharmaceutical Intermediate: A key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for compounds with phosphonate or phosphate ester moieties.
• Agrochemical Synthesis: Used in the production of advanced herbicides, insecticides, and plant growth regulators that require phosphorus-based functional groups.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized phosphine ligands and organocatalysts used in asymmetric synthesis and cross-coupling reactions.
• Polymer Modification: Employed to introduce reactive phosphorus-containing side chains into polymers, enhancing properties like flame retardancy or adhesion.
• Chemical Biology Probes: Useful for synthesizing affinity labels, enzyme inhibitors, or other molecular probes that target biological phosphate-binding sites.
• Material Science Research: Acts as a building block for novel organic-inorganic hybrid materials and surface functionalization agents.

Basic Information

Product Name	(2-Bromoethyl)-Phosphorylchloride
CAS No.	4167-02-6
Molecular Formula	C2H4BrClOP
Molecular Weight	191.38 g/mol
Synonyms	2-Bromoethylphosphonic Dichloride; (2-Bromoethyl)phosphonic Dichloride; 2-Bromoethylphosphonyl Chloride; Phosphonic Dichloride, (2-Bromoethyl)-; NSC 401122; (β-Bromoethyl)phosphonic Dichloride; 2-Bromoethanephosphonic Dichloride
EINECS	224-025-5

Quality Control

Our (2-Bromoethyl)-Phosphorylchloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chromatographic purity analysis and identity confirmation, to ensure it meets the high standards required for research and industrial synthesis. A Certificate of Analysis (COA) detailing specific results for purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, containers must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent decomposition. Keep away from heat, sparks, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.