Description

5’o-Tritylinosine is a protected nucleoside derivative, specifically an inosine molecule where the 5'-hydroxyl group is shielded by a trityl protecting group. This compound is a critical intermediate in the synthesis of oligonucleotides and modified nucleosides, enabling precise control over molecular structure during complex chemical reactions. It is essential for researchers and manufacturers in the fields of pharmaceutical development, antisense therapy, and molecular biology, where high-purity building blocks are required for creating advanced therapeutic agents and diagnostic tools.

Application

• Oligonucleotide Synthesis: Serves as a key phosphoramidite precursor in solid-phase synthesis for research and therapeutic oligonucleotides.
• Antisense & siRNA Drug Development: Used in the manufacture of modified nucleosides that enhance the stability and efficacy of gene-silencing drugs.
• Pharmaceutical Intermediates: Acts as a protected building block in the multi-step synthesis of novel antiviral and anticancer nucleoside analogs.
• Biochemical Research: Employed in studies exploring RNA structure, function, and enzyme mechanisms requiring specifically modified nucleotides.
• Diagnostic Probe Manufacture: Utilized in creating labeled nucleosides for diagnostic assays and hybridization probes.
• Scale-up GMP Production: Suitable for use in current Good Manufacturing Practice (cGMP) environments for the production of active pharmaceutical ingredients (APIs).

Basic Information

Product Name	5’o-Tritylinosine
CAS No.	4152-77-6
Molecular Formula	C29H26N4O5
Molecular Weight	510.54 g/mol
Synonyms	5'-O-Tritylinosine; 5'-O-(Triphenylmethyl)inosine; Inosine, 5'-O-trityl-; 9-[(5-O-Triphenylmethyl-β-D-ribofuranosyl)-9H-purin-6-ol]; NSC 113927; 5'-O-Trityl-9H-purin-6-ol riboside; 5'-O-Trityl-6-oxopurine riboside
EINECS	Contact for details

Quality Control

Every batch of 5’o-Tritylinosine is produced and tested under stringent quality management systems. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by HPLC, NMR, and mass spectrometry is supplied with each shipment. Our quality commitment aligns with the expectations of cGMP for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.