Description

4-Thio-Ump Disodium Salt is a chemically modified nucleotide analog of significant interest in biochemical and pharmaceutical research. This compound serves as a critical building block and research tool for studying enzyme mechanisms, nucleic acid interactions, and metabolic pathways. It is primarily utilized by research institutions, diagnostic kit manufacturers, and pharmaceutical companies engaged in the development of novel therapeutic agents and molecular probes. The product, identified by CAS number 4145-46-4, is handled with stringent quality control to ensure consistency for sensitive applications.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for thymidylate synthase and related enzymes.
• Pharmaceutical Intermediate: Serves as a key synthetic precursor in the development of potential anticancer and antiviral nucleoside analogs.
• Diagnostic Reagent Manufacturing: Incorporated into the synthesis of specialized probes and components for molecular diagnostic assays.
• Metabolic Pathway Analysis: Employed as a tracer or modulator in studies of nucleotide metabolism and cellular biosynthesis pathways.
• Enzyme Mechanism Elucidation: Acts as a tool compound to investigate the binding sites and catalytic actions of specific nucleotide-processing enzymes.

Basic Information

Product Name	4-Thio-Ump Disodium Salt
CAS No.	4145-46-4
Molecular Formula	C9H11N2Na2O8PS
Molecular Weight	392.19 g/mol
Synonyms	4-Thiouridine 5'-(disodium phosphate); 4-Thio-UMP disodium; 2'-Deoxy-4-thiouridine 5'-monophosphate disodium salt; 4-Thio-dUMP disodium; 4-Thio-2'-deoxyuridine 5'-monophosphate disodium salt; 4-S-dUMP Na2; 4-Thiouridylate disodium salt
EINECS	Contact for details

Quality Control

Our 4-Thio-Ump Disodium Salt is produced and tested under a rigorous quality management system. Each batch is analyzed to ensure high chemical purity and identity, with specifications aligned with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and performance consistency for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
pH (1% Solution)	6.0 - 8.0
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.