Description

2-Methylthioadenosine is a modified nucleoside derivative of adenosine, where a methylthio group replaces the hydroxyl group at the 2' position of the ribose sugar. This structural modification makes it a valuable biochemical tool and a key intermediate in the study of cellular metabolism and enzymatic processes. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for drug discovery, metabolic pathway analysis, and as a precursor for synthesizing more complex bioactive compounds. Its role in studying methylation and sulfur transfer reactions is of particular interest in biochemical research.

Application

• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly for methyltransferase and sulfur metabolism research.
• Pharmaceutical Intermediates: Serves as a key building block in the synthesis of novel nucleoside-based therapeutics and prodrugs.
• Metabolic Pathway Analysis: Employed as a tracer or standard in mass spectrometry and HPLC studies to investigate purine and methionine salvage pathways.
• Enzyme Kinetics: Utilized to study the kinetics and mechanism of action of enzymes like methylthioadenosine phosphorylase (MTAP).
• Cell Signaling Studies: Applied in research exploring the role of adenosine derivatives in cellular communication and regulation.
• Reference Standard: Used as a high-purity analytical standard for quality control in pharmaceutical manufacturing and research laboratories.

Basic Information

Product Name	2-Methylthioadenosine
CAS No.	4105-39-9
Molecular Formula	C11H15N5O4S
Molecular Weight	313.33 g/mol
Synonyms	2-Methylmercaptoadenosine; 2-(Methylthio)adenosine; 2-MTA; 2-Methylthio-Ado; NSC 37136; 9-β-D-Ribofuranosyl-2-(methylthio)adenine; 2-(Methylsulfanyl)adenosine
EINECS	223-888-7

Quality Control

Our 2-Methylthioadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture content. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, ensuring compliance with research and development grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.