Description

5'-Iodo-5'-Deoxyadenosine is a halogenated nucleoside derivative, a crucial building block in synthetic organic chemistry and life science research. This compound serves as a versatile intermediate for the synthesis of modified oligonucleotides and adenosine analogs with potential biological activity. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and diagnostic sectors for drug discovery, probe development, and biochemical studies.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel adenosine receptor agonists/antagonists and antiviral or anticancer nucleoside analogs.
• Oligonucleotide Synthesis: Used to incorporate iodine-labeled adenosine into DNA or RNA strands for structural studies, cross-linking experiments, or as a handle for further functionalization.
• Biochemical Probe Development: Acts as a substrate or inhibitor in enzymatic studies, particularly for kinases and other adenosine-metabolizing enzymes.
• Radioligand Precursor: Serves as a starting material for the synthesis of iodine-125 (125I) labeled tracers for receptor binding assays and imaging studies.
• Cross-coupling Reactions: The iodine atom makes it a valuable substrate for palladium-catalyzed cross-coupling reactions (e.g., Sonogashira, Suzuki) to create diverse adenosine libraries.
• Academic & Industrial Research: Fundamental research tool in medicinal chemistry and chemical biology for exploring nucleotide function and interaction.

Basic Information

Product Name	5'-Iodo-5'-Deoxyadenosine
CAS No.	4099-81-4
Molecular Formula	C10H12IN5O3
Molecular Weight	377.14 g/mol
Synonyms	5'-Deoxy-5'-iodoadenosine; 9-[(5-Deoxy-5-iodo-β-D-ribofuranosyl)]adenine; 5'-Iodo-5'-deoxyadenosine; 5'-Iodoadenosine; 5'-Iodo-5'-deoxy-D-adenosine; Adenosine, 5'-deoxy-5'-iodo-; 5'-Deoxy-5'-iodo-9-β-D-ribofuranosyladenine
EINECS	Contact for details

Quality Control

Our 5'-Iodo-5'-Deoxyadenosine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.