Description

3β-(Acetyloxy)-14-Hydroxy-5β-Bufa-20,22-Dienolide is a high-purity, specialized bufadienolide derivative of significant interest in advanced pharmaceutical research and development. This compound serves as a critical intermediate and reference standard for the synthesis and study of novel cardioactive steroids and other biologically active molecules. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing new therapeutic agents and analytical methods.

Application

• Pharmaceutical Intermediate: A key building block in the synthetic pathways for novel cardiac glycosides and other steroid-based therapeutics.
• Reference Standard: Used in analytical chemistry for method development, validation, and quality control (QC) of related compounds in pharmaceutical preparations.
• Biochemical Research: Employed in pharmacological studies to investigate structure-activity relationships (SAR) of bufadienolides and their interactions with biological targets like the Na⁺/K⁺-ATPase enzyme.
• Fine Chemical Synthesis: Serves as a precursor for the preparation of more complex, modified steroid derivatives with potential biological activity.
• Academic Research: Utilized in university and institutional labs for fundamental studies in medicinal chemistry, natural product chemistry, and toxicology.

Basic Information

Product Name	3β-(Acetyloxy)-14-Hydroxy-5β-Bufa-20,22-Dienolide
CAS No.	4029-66-7
Molecular Formula	C₂₆H₃₆O₅
Molecular Weight	428.56 g/mol
Synonyms	14-Hydroxy-3β-acetoxy-5β-bufa-20,22-dienolide; 3β-Acetoxy-14-hydroxy-5β-bufa-20,22-dienolide; Bufadienolide derivative; 3β-Acetoxy-14-hydroxybufa-20,22-dienolide; Acetylated bufalin derivative; 5β-Bufa-20,22-dienolide-3β,14-diol 3-acetate; 4029-66-7; NSC 83688
EINECS	Contact for details

Quality Control

Our 3β-(Acetyloxy)-14-Hydroxy-5β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis, to ensure it meets the high standards required for research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and reliability for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.