Description

3β-Acetoxy-16β-Hydroxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide is a highly specialized bufadienolide derivative, a class of compounds known for their potent biological activity. This compound serves as a critical advanced pharmaceutical intermediate for the research and development of novel therapeutic agents. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers focused on cardiology, oncology, and steroid-based drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel cardiac glycosides and other steroid-based active pharmaceutical ingredients (APIs).
• Biochemical Research: Used as a reference standard and probe compound in pharmacological studies targeting Na+/K+-ATPase enzyme activity.
• Preclinical Development: Serves as a starting material for the development of potential anti-cancer and cardiotonic drug candidates.
• Fine Chemical Synthesis: Employed in complex organic synthesis routes to create structurally related bufadienolide analogs for structure-activity relationship (SAR) studies.

Basic Information

Product Name	3β-Acetoxy-16β-Hydroxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide
CAS No.	4026-96-4
Molecular Formula	C₂₆H₃₄O₇
Molecular Weight	458.55 g/mol
Synonyms	14β,15β-Epoxy-3β-acetoxy-16β-hydroxybufa-20,22-dienolide; 3β-Acetoxy-16β-hydroxy-14β,15β-epoxy-5β-bufa-20,22-dienolide; 3β-Acetoxy-14β,15β-epoxy-16β-hydroxy-5β-bufa-20,22-dienolide; Bufadienolide derivative; 4026-96-4; 14,15-Epoxy-3-acetoxy-16-hydroxybufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our 3β-Acetoxy-16β-Hydroxy-14,15β-Epoxy-5β-Bufa-20,22-Dienolide is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, IR, MS). We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or manufacturing specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.