Description

Cyclopropanecarbonyl Chloride is a versatile and highly reactive organic acid chloride building block. This compound is essential for introducing the compact, strained cyclopropane ring into target molecules, a key structural motif in medicinal chemistry and advanced material synthesis. It is primarily used by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs) containing the cyclopropane moiety, which is valued for its metabolic stability and conformational rigidity.
• Agrochemical Synthesis: Used in the production of novel herbicides, fungicides, and insecticides where the cyclopropane group can enhance biological activity.
• Peptide Mimetics & Bioisosteres: Employed in medicinal chemistry to create cyclopropane-containing amino acid analogs and other bioisosteric replacements.
• Material Science Precursor: Serves as a monomer or cross-linking agent in the synthesis of specialized polymers and advanced organic materials.
• Chemical Research & Development: A fundamental reagent in organic synthesis laboratories for C-C and C-N bond formation via acylations and other nucleophilic substitution reactions.
• Ligand & Catalyst Preparation: Used to functionalize ligands and complexing agents for catalytic systems and metal-organic frameworks (MOFs).

Basic Information

Product Name	Cyclopropanecarbonyl Chloride
CAS No.	4023-34-1
Molecular Formula	C4H5ClO
Molecular Weight	104.54 g/mol
Synonyms	Cyclopropanecarboxylic acid chloride; Cyclopropanoyl chloride; Cyclopropanecarboxylic chloride; Cyclopropanecarbonyl chloride; Cyclopropanecarboxychloride; Cyclopropylcarbonyl chloride; Cyclopropane-1-carbonyl chloride
EINECS	223-696-5

Quality Control

Our Cyclopropanecarbonyl Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC, HPLC, and NMR, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and reacts violently with water, strong bases, and oxidizing agents. Keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to maintain product integrity.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.