Description

5-α-Pregnan-3-Alpha, 11-Beta, 17,21-Tetrol-20-One 3,21-Diacetate is a high-purity steroid derivative and key pharmaceutical intermediate. This compound is valued for its specific stereochemistry and functional groups, making it a critical building block in the synthesis of advanced steroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical R&D laboratories and manufacturers specializing in corticosteroid and neurosteroid production.

Application

• Pharmaceutical Intermediate: A crucial precursor in the multi-step synthesis of potent corticosteroid drugs.
• Research & Development: Used in academic and industrial laboratories for studying steroid metabolism, receptor interactions, and structure-activity relationships (SAR).
• Reference Standard: Serves as a certified reference material (CRM) for analytical method development and quality control in pharmaceutical analysis.
• Neurosteroid Synthesis: Potential intermediate in the research-scale preparation of neuroactive steroids that modulate the central nervous system.
• Process Chemistry: Employed in scaling up and optimizing manufacturing routes for complex steroid molecules.

Basic Information

Product Name	5-α-Pregnan-3-Alpha, 11-Beta, 17,21-Tetrol-20-One 3,21-Diacetate
CAS No.	4004-70-0
Molecular Formula	C25H36O7
Molecular Weight	448.55 g/mol
Synonyms	11β,17,21-Trihydroxy-5α-pregnan-20-one 3,21-diacetate; 3α,21-Diacetoxy-11β,17-dihydroxy-5α-pregnan-20-one; 5α-Pregnane-3α,11β,17,21-tetrol-20-one 3,21-diacetate; 11β-Hydroxycorticosterone 3,21-diacetate; Tetrahydrocorticosterone 3,21-diacetate; 5α-Tetrahydrocorticosterone 3,21-diacetate; 3α,21-Diacetyloxy-11β,17-dihydroxy-5α-pregnan-20-one
EINECS	Contact for details

Quality Control

Our 5-α-Pregnan-3-Alpha, 11-Beta, 17,21-Tetrol-20-One 3,21-Diacetate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the stringent requirements for pharmaceutical intermediate use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.