Description

Hydroxy-[[3-Hydroxy-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-Oxolan-2-Yl]Methoxy]Phosphoryl]Oxyphosphonic Acid is a high-purity nucleotide derivative and a key phosphorylated intermediate in biochemical synthesis. This compound is critical for research and development in life sciences, offering a precise building block for modifying nucleic acid structures and studying enzymatic pathways. It is primarily utilized by pharmaceutical R&D teams, diagnostic reagent manufacturers, and academic research institutions focused on nucleotide chemistry, antiviral drug development, and molecular biology.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel nucleoside analogs and prodrugs for antiviral and anticancer research.
• Biochemical Research: Used as a substrate or inhibitor in enzymatic studies, particularly those involving kinases, polymerases, and other phosphotransferase enzymes.
• Diagnostic Reagent Manufacturing: Employed in the production of specialized reagents for molecular diagnostics, including probes and primers.
• Nucleotide Chemistry: Acts as a modified nucleotide precursor for studying RNA/DNA structure, function, and stability.
• Life Science Tool Development: Incorporated into the development of research tools such as labeled nucleotides for sequencing and microarray applications.

Basic Information

Product Name	Hydroxy-[[3-Hydroxy-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-Oxolan-2-Yl]Methoxy]Phosphoryl]Oxyphosphonic Acid
CAS No.	491-97-4
Molecular Formula	C10H15N2O12P2
Molecular Weight	417.18 g/mol
Synonyms	Thymidine 5'-Diphosphate; TDP; Thymidine 5'-pyrophosphate; 5'-TDP; Thymidine diphosphate; dTDP; 2'-Deoxythymidine 5'-diphosphate; Thymidine 5'-(trihydrogen diphosphate)
EINECS	207-755-9

Quality Control

Our Hydroxy-[[3-Hydroxy-5-(5-Methyl-2,4-Dioxo-Pyrimidin-1-Yl)-Oxolan-2-Yl]Methoxy]Phosphoryl]Oxyphosphonic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider desiccated or inert atmosphere conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Solubility	Soluble in water, slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.