Description

(13α)-3-Hydroxyestra-1,3,5(10)-Trien-17-One CAS NO 474-84-0 is a high-purity steroid derivative, specifically an estrone-related compound. It serves as a critical intermediate in the synthesis of complex steroid hormones and active pharmaceutical ingredients (APIs). This compound is essential for pharmaceutical R&D, analytical reference standards, and fine chemical manufacturing. Its defined structure and purity make it a valuable building block for producing specialized therapeutic agents.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of steroidal drugs, including hormone therapies and anti-inflammatory agents.
• Research & Development: Used as a reference standard and starting material in medicinal chemistry and biochemical research.
• Analytical Chemistry: Serves as a certified reference material (CRM) for method development, validation, and quality control in laboratories.
• Fine Chemical Synthesis: Building block for creating custom steroid derivatives and other high-value specialty chemicals.
• Biochemical Studies: Utilized in studies investigating estrogen receptor interactions and metabolic pathways.

Basic Information

Product Name	(13α)-3-Hydroxyestra-1,3,5(10)-Trien-17-One
CAS No.	474-84-0
Molecular Formula	C18H22O2
Molecular Weight	270.37 g/mol
Synonyms	13α-Hydroxyestra-1,3,5(10)-trien-17-one; 13α-Hydroxy-17-oxoestra-1,3,5(10)-triene; 13α-Hydroxyestrone; 13-epi-Estrone; 17-Oxo-13α-estra-1,3,5(10)-trien-3-ol; NSC 121773
EINECS	207-477-4

Quality Control

Our (13α)-3-Hydroxyestra-1,3,5(10)-Trien-17-One is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy. We provide Certificates of Analysis (COA) with detailed specifications for traceability and quality assurance, supporting compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.