Description

Bufotaline is a potent cardioactive steroid compound, a key bufadienolide found in the venom and skin secretions of toads of the genus *Bufo*. This high-purity reference standard is critical for ensuring analytical accuracy and consistency in research and development. It is primarily utilized by pharmaceutical researchers, analytical laboratories, and manufacturers in the life sciences sector for applications ranging from pharmacological studies to quality control of related products.

Application

• Pharmaceutical Reference Standard: Serves as a primary analytical standard for the identification, assay, and purity testing of bufadienolide-containing products and traditional medicines.
• Biochemical Research: Used in pharmacological studies to investigate its effects on cardiac function, sodium-potassium ATPase inhibition, and potential anti-cancer properties.
• Toxicology & Forensics: Employed as a calibrant in analytical methods (HPLC, LC-MS) for the detection and quantification of bufotaline in biological samples, food supplements, or traditional remedy adulteration cases.
• Natural Product Isolation & Characterization: Acts as a benchmark compound in the isolation, purification, and structural confirmation of related steroid compounds from natural sources.
• Quality Control (QC) & Quality Assurance (QA): Essential for in-house method development and validation within QC laboratories of manufacturers dealing with herbal extracts or related APIs.

Basic Information

Product Name	Bufotaline
CAS No.	471-95-4
Molecular Formula	C26H36O6
Molecular Weight	444.56 g/mol
Synonyms	14β,15β-Epoxy-3β-hydroxy-5β-bufa-20,22-dienolide; Bufotalin; 3β-Hydroxy-14,15-epoxy-5β-bufa-20,22-dienolide; Bufogenin B; NSC 1895; Venobufagin; Bufotaline (VAN)
EINECS	207-429-6

Quality Control

Our Bufotaline is produced and handled under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with your research or manufacturing standards. For specific pharmacopeial (e.g., USP) or custom specifications, please contact our technical team.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.