Description

Marinobufagenin CAS NO 470-42-8 is a cardioactive steroid and a bufadienolide compound of significant interest in biochemical research. Its primary value lies in its role as a specific endogenous Na+,K+-ATPase inhibitor, making it a critical tool for studying cardiovascular physiology and related signaling pathways. This high-purity compound is essential for researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors, particularly those focused on hypertension, heart failure, and novel therapeutic target discovery.

Application

• Biomedical Research: Used as a specific probe to study the role of endogenous cardiotonic steroids in cardiovascular diseases, hypertension, and renal function.
• Pharmaceutical Development: Serves as a reference standard and a key starting material in drug discovery programs targeting Na+,K+-ATPase and its associated pathways.
• In Vitro Diagnostics: Employed in the development and calibration of immunoassays designed to detect and quantify marinobufagenin levels in biological samples.
• Mechanistic Studies: Facilitates research into cellular signaling, ion transport mechanisms, and the pathophysiology of preeclampsia and other conditions linked to endogenous digitalis-like factors.
• Academic Research: A vital reagent for universities and research institutes conducting studies in pharmacology, endocrinology, and molecular biology.

Basic Information

Product Name	Marinobufagenin
CAS No.	470-42-8
Molecular Formula	C24H32O5
Molecular Weight	400.51 g/mol
Synonyms	MBG; 3β,5β,14β-Trihydroxy-19-oxobufa-20,22-dienolide; 14β,15β-Epoxy-3β-hydroxy-5β-card-20(22)-enolide; Bufogenin B; Marinobufagin; Telocinobufagin; 3β-Hydroxy-14,15-epoxy-5β-bufa-20,22-dienolide
EINECS	Contact for details

Quality Control

Our Marinobufagenin is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency suitable for research applications. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.