Description

(25S)-Spirost-5-Ene-2α,3β-Diol is a high-purity steroidal sapogenin, a key intermediate in the synthesis of various bioactive compounds. Its defined stereochemistry and structural integrity are critical for ensuring the efficacy and consistency of downstream pharmaceutical products. This compound is essential for research and manufacturing in the pharmaceutical and biotechnology sectors, particularly for the development of steroidal drugs and hormone analogs.

Application

• Pharmaceutical Intermediate: A crucial starting material for the semi-synthesis of steroidal drugs, including corticosteroids, sex hormones, and diuretic agents.
• Biochemical Research: Used as a reference standard and precursor in metabolic pathway studies and steroid receptor research.
• Natural Product Synthesis: Serves as a chiral building block for the total synthesis of complex natural products derived from plant saponins.
• API Development: Employed in the research and development of new Active Pharmaceutical Ingredients (APIs) with steroidal backbones.
• Cosmetic Ingredient Synthesis: A precursor for synthesizing certain bioactive compounds used in high-end skincare formulations.

Basic Information

Product Name	(25S)-Spirost-5-Ene-2α,3β-Diol
CAS No.	469-99-8
Molecular Formula	C27H42O4
Molecular Weight	430.62 g/mol
Synonyms	Diosgenin; (25R)-Spirost-5-en-3β-ol; Nitogenin; Dioscorea Sapogenin; 3β-Hydroxy-5-spirosten; (3β,25R)-Spirost-5-en-3-ol; Smilagenin (Note: Smilagenin is the (25S) epimer); Tigogenin (Note: Tigogenin is the 5α-saturated analog)
EINECS	207-425-2

Quality Control

Our (25S)-Spirost-5-Ene-2α,3β-Diol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) are provided with every shipment, detailing all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Melting Point	204°C - 210°C
Specific Rotation	-120° to -130° (c=1 in CHCl3)
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.