Description

3β-Hydroxy-15-Oxo-5β,14β-Bufa-20,22-Dienolide is a high-purity bufadienolide derivative, a class of compounds known for their potent biological activity. This specific steroid-like molecule is a critical intermediate and reference standard in advanced pharmaceutical research and development. It is primarily utilized by research institutions and pharmaceutical companies focused on cardiovascular therapeutics, oncology, and the study of Na+/K+-ATPase inhibitors.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel cardiac glycosides and other therapeutic agents.
• Biochemical Research: Used as a reference standard in studies investigating the mechanism of Na+/K+-ATPase inhibition and its physiological effects.
• Drug Discovery: Serves as a lead compound or pharmacophore model for developing new treatments for heart failure and certain cancers.
• Analytical Standard: Employed in HPLC, LC-MS, and NMR for method development, calibration, and quality control of related substances.
• Toxicology Studies: Used in research to understand the activity and metabolism of bufadienolides.

Basic Information

Product Name	3β-Hydroxy-15-Oxo-5β,14β-Bufa-20,22-Dienolide
CAS No.	468-87-1
Molecular Formula	C₂₄H₃₂O₄
Molecular Weight	384.51 g/mol
Synonyms	15-Oxobufalin; 3β-Hydroxy-14β,15β-epoxy-5β-bufa-20,22-dienolide; Bufadienolide A; 15-Oxo-14,15-dihydrobufalin; 3β,14β-Dihydroxy-15-oxo-5β-bufa-20,22-dienolide; 468-87-1; NSC 75696
EINECS	Contact for details

Quality Control

Every batch of 3β-Hydroxy-15-Oxo-5β,14β-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC for purity and identity confirmation via NMR and MS, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and analytical methods is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.