Description

3β,14-Dihydroxy-19-Oxo-5α-Bufa-20,22-Dienolide is a specialized bufadienolide compound with a complex steroidal structure. This high-purity intermediate is critical for pharmaceutical research and development, particularly in the study of cardiac glycosides and their biological activities. It serves as a key building block for medicinal chemists and research institutions focused on oncology, cardiology, and novel therapeutic discovery.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for quality control and analytical method development in drug manufacturing.
• Active Pharmaceutical Ingredient (API) Intermediate: Serves as a crucial synthetic precursor in the production of specialized cardiac glycosides and related therapeutic agents.
• Biochemical Research: Employed in pharmacological studies to investigate Na+/K+-ATPase inhibition, cell signaling pathways, and mechanisms of action for potential cancer therapies.
• Academic & Discovery Chemistry: A valuable tool for structure-activity relationship (SAR) studies and the synthesis of novel bufadienolide analogs in university and industrial R&D labs.
• Analytical Testing: Functions as a high-purity standard for HPLC, LC-MS, and NMR analysis in contract research organizations (CROs) and quality assurance laboratories.

Basic Information

Product Name	3β,14-Dihydroxy-19-Oxo-5α-Bufa-20,22-Dienolide
CAS No.	468-18-8
Molecular Formula	C₂₄H₃₂O₅
Molecular Weight	400.51 g/mol
Synonyms	19-Oxocinobufagin; 3β,14-Dihydroxy-19-oxo-5α-bufa-20,22-dienolide; 19-Oxo-cinobufagin; Bufa-20,22-dienolide, 3,14-dihydroxy-19-oxo-, (3β,5α)-; NSC 163044; Cinobufagin 19-aldehyde
EINECS	Contact for details

Quality Control

Our 3β,14-Dihydroxy-19-Oxo-5α-Bufa-20,22-Dienolide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with research-grade standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry environment. For long-term storage, consider storing under inert atmosphere at -20°C to ensure maximum stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.