Description

Oleandrin CAS NO 465-16-7 is a potent cardiac glycoside and the primary active constituent derived from the leaves of the oleander plant (*Nerium oleander*). This compound is of significant interest for its specific biochemical activity, serving as a critical reference standard and research material in the life sciences. It is essential for researchers and developers in the pharmaceutical, biotechnology, and natural product sectors who require high-purity, well-characterized bioactive compounds for analytical and investigative purposes.

Application

• Pharmaceutical Reference Standard: Used as a primary standard in HPLC, LC-MS, and other analytical methods for the identification and quantification of oleandrin and related compounds in drug development and quality control.
• Biochemical Research: Serves as a key tool compound in pharmacological studies investigating Na+/K+-ATPase inhibition, cardiac function, and intracellular signaling pathways.
• Natural Product Isolation & Analysis: Employed as a benchmark in the extraction, purification, and characterization processes of plant-derived cardiac glycosides.
• Toxicology Studies: Used in forensic and clinical toxicology laboratories to develop and validate assays for detecting oleandrin poisoning.
• Academic Research: Fundamental for university and institutional research exploring the chemistry, biosynthesis, and biological activities of cardenolides.
• Method Development & Validation: Critical for developing new analytical methodologies in compliance with regulatory guidelines (e.g., ICH, FDA) for complex natural products.

Basic Information

Product Name	Oleandrin
CAS No.	465-16-7
Molecular Formula	C32H48O9
Molecular Weight	576.73 g/mol
Synonyms	Neriantin; Oleandrine; Foliandrin; Corrigen; Anvirzel (as a component); 16β-Acetoxy-14-hydroxy-3β-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]card-20(22)-enolide; (3β,16β)-16-(Acetyloxy)-14-hydroxy-3-[(2,6-dideoxy-3-O-methyl-α-L-arabino-hexopyranosyl)oxy]card-20(22)-enolide
EINECS	207-366-9

Quality Control

Our Oleandrin is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and reliability for research applications. Each lot is subjected to comprehensive analytical testing, including identity confirmation by spectroscopic methods and purity assessment by HPLC. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a low-humidity environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.