Description

Gamabufotalin CAS NO 465-11-2 is a bioactive bufadienolide compound, a key constituent derived from traditional medicinal sources. This high-purity chemical is valued for its role as a critical reference standard and active pharmaceutical ingredient (API) in advanced research and development. It is essential for pharmaceutical companies, biotechnology research institutions, and academic laboratories focused on oncology, cardiology, and natural product chemistry.

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the quality control and quantification of bufadienolides in drug formulations and herbal extracts.
• Active Pharmaceutical Ingredient (API) Research: Serves as a key intermediate or core structure in the R&D of novel therapeutic agents, particularly in anti-cancer and cardiotonic drug discovery.
• Biochemical & Pharmacological Studies: Employed in in vitro and in vivo studies to investigate mechanisms of action, cytotoxicity, and signal transduction pathways.
• Natural Product Isolation & Analysis: Acts as a benchmark for the isolation, purification, and analytical method development (e.g., HPLC, LC-MS) of related compounds from natural sources.
• Academic & Institutional Research: Utilized in universities and research institutes for fundamental studies in medicinal chemistry and toxicology.

Basic Information

Product Name	Gamabufotalin
CAS No.	465-11-2
Molecular Formula	C₂₄H₃₂O₆
Molecular Weight	416.51 g/mol
Synonyms	Gamabufotalin; 3β,14β-Dihydroxy-5β-bufa-20,22-dienolide; 14β-Hydroxy-3β-(β-D-glucopyranosyloxy)-5β-bufa-20,22-dienolide (aglycone); Bufotalin derivative; Chan Su constituent; Toad venom compound; Bufadienolide CPD-1
EINECS	Contact for details

Quality Control

Our Gamabufotalin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, IR and NMR for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports applications requiring high-purity reference standards and pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a desiccated environment and handled under appropriate conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.