Description

4-Fluorophenylacetyl Chloride is a versatile and reactive aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in its ability to efficiently introduce the 4-fluorophenylacetyl moiety, a key structural motif in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This high-purity intermediate is essential for research and production chemists in the pharmaceutical, agrochemical, and specialty chemical industries seeking to develop novel compounds with enhanced biological activity.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of central nervous system (CNS) agents and anti-inflammatory drugs.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the fluorine atom enhances metabolic stability and bioactivity.
• Peptide Mimetics & Modifications: Employed to acylate amino groups, creating peptide analogs and modifying biomolecules for research and therapeutic applications.
• Liquid Crystal & OLED Material Precursor: Serves as a starting material for synthesizing fluorinated aromatic compounds used in electronic displays and organic light-emitting diodes.
• Polymer Chemistry: Acts as a monomer or modifying agent in the production of specialty polymers with specific thermal or chemical resistance properties.
• Chemical Research & Development: A fundamental reagent in academic and industrial R&D labs for exploring new synthetic routes and creating novel fluorinated compounds.

Basic Information

Product Name	4-Fluorophenylacetyl Chloride
CAS No.	459-04-1
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2-(4-Fluorophenyl)acetyl Chloride; p-Fluorophenylacetyl Chloride; 4-Fluorobenzeneacetyl Chloride; (4-Fluorophenyl)acetic Acid Chloride; 2-(4-Fluorophenyl)ethanoyl Chloride; 4-Fluorophenacetyl Chloride; NSC 406916
EINECS	Contact for details

Quality Control

Our 4-Fluorophenylacetyl Chloride is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and consistency. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis and degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and amines.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.