Description

α-(Aminomethyl)-4-Fluorobenzyl Alcohol is a versatile bifunctional organic intermediate containing both an amino and a hydroxyl group on a fluorinated aromatic backbone. This unique structure makes it a valuable building block for the synthesis of more complex molecules, particularly in the pharmaceutical and agrochemical sectors. It is primarily sought after by R&D chemists and process development scientists for creating active pharmaceutical ingredients (APIs), advanced agrochemicals, and specialty fine chemicals.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and stability.
• Ligand and Catalyst Preparation: Serves as a starting material for creating chiral ligands and metal-organic complexes used in asymmetric catalysis.
• Polymer Modification: Functional monomer for introducing fluorinated and reactive amino/hydroxyl sites into specialty polymers and resins.
• Peptidomimetics Research: Building block for constructing non-natural amino acid analogs and peptide-like structures in medicinal chemistry.
• Cross-coupling Reactions: Useful substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) to create complex biaryl structures.

Basic Information

Product Name	α-(Aminomethyl)-4-Fluorobenzyl Alcohol
CAS No.	456-05-3
Molecular Formula	C8H10FNO
Molecular Weight	155.17 g/mol
Synonyms	(4-Fluorophenyl)(hydroxymethyl)methanamine; 4-Fluoro-α-(aminomethyl)benzyl alcohol; 1-(Aminomethyl)-1-(4-fluorophenyl)methanol; 4-Fluoro-α-(aminomethyl)benzenemethanol; (4-Fluorobenzyl)aminomethanol; 4-Fluoro-α-(hydroxymethyl)benzylamine; α-Amino-4-fluorobenzyl alcohol; (Aminomethyl)(4-fluorophenyl)methanol
EINECS	Contact for details

Quality Control

Our α-(Aminomethyl)-4-Fluorobenzyl Alcohol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and tests for residual solvents and moisture. A Certificate of Analysis (COA) documenting all specifications is provided with every shipment to ensure traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere (e.g., nitrogen) for long-term storage to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.