Description

3-(Fluorosulphonyl)Benzoyl Chloride is a highly reactive and versatile aromatic acid chloride derivative, distinguished by the presence of both a fluorosulfonyl and an acid chloride functional group. This unique bifunctional structure makes it a critical building block for synthesizing advanced intermediates in pharmaceutical and agrochemical research. It is particularly valuable for medicinal chemists and process development scientists working on sulfonamide-based active ingredients. The compound, with CAS No. 454-93-3, is essential for introducing the fluorosulfonyl moiety into target molecules under controlled conditions.

Application

This specialized reagent serves as a key precursor in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: Synthesis of novel sulfonamide drugs, including kinase inhibitors, diuretics, and antimicrobial agents.
• Agrochemical Active Ingredient Development: Building block for herbicides, fungicides, and insecticides that incorporate the fluorosulfonyl group for enhanced bioactivity.
• Material Science: Monomer for creating specialized polymers and advanced materials with unique surface properties.
• Chemical Research & Development: A versatile electrophile for constructing complex molecular architectures in academic and industrial R&D settings.
• Ligand Synthesis: Preparation of specialized ligands for catalysis and metal-organic frameworks (MOFs).

Basic Information

Product Name	3-(Fluorosulphonyl)Benzoyl Chloride
CAS No.	454-93-3
Molecular Formula	C7H4ClFO3S
Molecular Weight	222.62 g/mol
Synonyms	3-(Fluorosulfonyl)benzoyl chloride; m-(Fluorosulfonyl)benzoyl chloride; Benzoic acid, 3-(fluorosulfonyl)-, chloride; 3-Fluorosulfonylbenzoyl chloride; 454-93-3; 3-FSO2-Benzoyl chloride
EINECS	Contact for details

Quality Control

Our 3-(Fluorosulphonyl)Benzoyl Chloride is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. We provide comprehensive analytical data to support your projects. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every batch upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent hydrolysis. Keep away from strong bases, oxidizing agents, and alcohols.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.