Description

2,2,2-Trifluoro-1-(3-Nitrophenyl)-Ethanol is a versatile fluorinated aromatic alcohol building block of significant interest in advanced organic synthesis. Its unique structure, combining a trifluoroethanol moiety with a nitro-substituted phenyl ring, makes it a critical intermediate for constructing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: A key chiral precursor for the synthesis of active pharmaceutical ingredients (APIs), especially those requiring fluorinated motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Liquid Crystal & OLED Materials: Serves as a building block for fluorinated components in electronic display materials and organic light-emitting diodes (OLEDs).
• Advanced Polymer Chemistry: Incorporated as a monomer or modifier to create specialty polymers with unique solubility, thermal stability, and surface properties.
• Catalyst & Ligand Development: Utilized in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis.
• Chemical Research & Development: A valuable reagent for exploring new fluorination reactions and constructing complex molecular architectures in academic and industrial R&D settings.

Basic Information

Product Name	2,2,2-Trifluoro-1-(3-Nitrophenyl)-Ethanol
CAS No.	453-77-0
Molecular Formula	C8H6F3NO3
Molecular Weight	221.13 g/mol
Synonyms	1-(3-Nitrophenyl)-2,2,2-trifluoroethanol; 3-Nitro-α-(trifluoromethyl)benzyl alcohol; α-(Trifluoromethyl)-3-nitrobenzenemethanol; 2,2,2-Trifluoro-1-(3-nitrophenyl)ethan-1-ol; 3-Nitro-α,α,α-trifluorotoluene alcohol; m-Nitro-α-(trifluoromethyl)benzyl alcohol; 1-(m-Nitrophenyl)-2,2,2-trifluoroethanol
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoro-1-(3-Nitrophenyl)-Ethanol is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Specific Rotation (if chiral)	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.