Description

2-(2'-Fluorophenyl)-Acetyl-Chloride is a specialized aromatic acid chloride derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in its reactive carbonyl chloride group, which facilitates efficient acylation reactions to introduce the 2-fluorobenzyl structural motif. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, where it is used to synthesize novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and other therapeutic areas.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, leveraging the fluorophenyl group for enhanced biological activity and stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in asymmetric catalysis and metal-organic frameworks (MOFs).
• Material Science Research: Employed in the synthesis of monomers and polymers with specific optical or electronic properties for advanced materials.
• Custom Chemical Synthesis: A versatile reagent for contract research organizations (CROs) and CDMOs performing custom acylation reactions for client projects.
• Fluorine Chemistry Studies: Important compound for academic and industrial research focused on the effects of fluorine substitution on reactivity and molecular properties.

Basic Information

Product Name	2-(2'-Fluorophenyl)-Acetyl-Chloride
CAS No.	451-81-0
Molecular Formula	C8H6ClFO
Molecular Weight	172.58 g/mol
Synonyms	2-Fluorophenylacetyl Chloride; (2-Fluorophenyl)acetyl Chloride; α-Chloro-2-fluoroacetophenone; 2-Fluoro-α-chloroacetophenone; 2-Fluorobenzeneacetyl Chloride; o-Fluorophenylacetyl Chloride; 2-(2-Fluorophenyl)acetyl Chloride; NSC 406913
EINECS	Contact for details

Quality Control

Our 2-(2'-Fluorophenyl)-Acetyl-Chloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment ensures the material is suitable for demanding applications in cGMP and research environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, open flames, and incompatible materials such as bases, alcohols, and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.