Description

Lithocholic Acid is a secondary bile acid, a key metabolic derivative formed by bacterial action in the intestines. It is a critical biochemical tool for studying bile acid metabolism, receptor interactions, and their roles in digestive and metabolic pathways. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, life science, and fine chemical sectors, where precise biochemical intermediates are required.

Application

• Pharmaceutical Research & Development: Serves as a key intermediate and reference standard in the synthesis and study of novel therapeutic agents targeting nuclear receptors like FXR (Farnesoid X Receptor).
• Biochemical & Metabolic Studies: Used as a critical reagent to investigate bile acid metabolism, cholestasis, and their signaling pathways in cellular and animal models.
• Reference Standard Material: Employed as a high-purity calibrant in analytical laboratories for HPLC, LC-MS, and other chromatographic methods to quantify bile acids in biological samples.
• Fine Chemical Synthesis: Acts as a versatile building block for the chemical synthesis of more complex bile acid derivatives and steroid-based compounds.
• Cell Culture & Microbiology: Utilized in specialized cell culture media and in studies examining the impact of bile acids on gut microbiota and intestinal health.

Basic Information

Product Name	Lithocholic Acid
CAS No.	434-13-9
Molecular Formula	C24H40O3
Molecular Weight	376.57 g/mol
Synonyms	3α-Hydroxy-5β-cholan-24-oic acid; LCA; 5β-Cholan-24-oic acid-3α-ol; Desoxycholic acid (obsolete); 3α-Hydroxycholanoic acid; Lithocholate; NSC 93817
EINECS	207-104-5

Quality Control

Our Lithocholic Acid is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including identity confirmation by IR spectroscopy and purity determination by HPLC, to ensure it meets stringent specifications for research and industrial use. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 98.0%
Melting Point	184 - 189 °C
Loss on Drying	≤ 1.0 %
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.1 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.